Continuous manufacturing process for solid forms

"Cahiers Techniques" Collection of the IMT Group. Book written in English.

Continuous manufacturing of solid dosage forms is a recent advancement in the pharmaceutical sector, offering superior efficiency, quality control, and environmental sustainability compared to traditional batch methods.

This process relies on the integration of Process Analytical Technology (PAT) for real-time monitoring and precise control of product attributes. To overcome operational challenges, innovative and modular equipment is being developed, along with raw materials whose role is critical. Although widespread industrial adoption is still limited, the potential for rapid scalability and customization of continuous manufacturing is immense.

Its future expansion is anticipated and promises to streamline drug development, enhance production efficiency, and optimize product quality.

 

Table of Contents

Part 1 – current situation / state of play

1. Context

2. Update on existing processes, in batch mode

Part 2 – continuous processes for solid dose manufacturing

2.1. Continuous direct compression

2.2. Continuous wet granulation

2.3. Twin screw granulation

2.4. Dry granulation as a twin-screw process in pharmaceutical applications – a case study

2.5. Continuous twin-screw granulation – what to consider in process design, development and scale-up

2.6. Tableting

2.7. Continuous film coating

Part 3 – pat and automation

3.1. Introduction

3.2. Spectroscopic sensors as pat tools

3.3. Data analysis and process modelling

3.4. Automation

3.5. Example of use cases

Part 4 – regulatory

Part 5 – raw materials

5.1. Excipients

5.2. Technical coprocessed excipients

5.3. Content uniformity of the tablets

5.4. Fixity of co-processed excipients supply

5.5. Performance of a premix system

5.6. Regulatory aspect for the co-processed excipients

 

With :

92 pages

Legal copyright — 1st edition: 2025, October IMT Editions

Références

ISBN 979-10-95285-12-0

EAN  9791095285120